Acting on a tip-off from a local informant, the police set up a strategic checkpoint at Kadjebi-Okanta, along the Eastern Corridor Road.
During the operation, authorities discovered several tons of marijuana hidden in concealed compartments of a long truck.
The driver and his accomplice, who were immediately arrested, are under investigation.
The seizure according to a report by adomonline.com formed part of ongoing efforts to curb drug trafficking in the region.
The Volta Regional Police has reiterated its commitment to combating drug trafficking and ensuring the safety of residents.
Investigations are ongoing to identify other individuals involved and to dismantle the larger drug trafficking networks operating in the area.