The 20-year-old was called up to beef up the Black Meteors squad to face Algeria in back-to-back games for a place in this year’s U23 Africa Cup of Nations.
However, the former AS Roma youngster has rejected the call despite his club’s acceptance to join the rest of the team.
GHANAsoccernet.com can reveal the Ghana FA has sent all travelling requirements to the Serie A club but the player has decided not to turn up to join Ibrahim Tanko’s side.
Afena-Gyan was an instrumental member of the Ghana squad that saw off Nigeria in the 2022 World Cup qualifying playoff in March last year
He was then snubbed for the final World Cup tournament in Qatar after he was omitted from the final squad list named by Otto Addo.
Afena-Gyan joined the newly-promoted Serie A side Cremonese in the summer from Roma for around US$ 7 million in a permanent deal.
He is yet to score in the Italian top-flight this campaign having provided one assist after 16 appearances.
He has scored twice in three matches in the Coppa Italia where Cremonese have reached the semi-finals after eliminating Napoli and Roma in the process.